Shogaol

Overview
Catalog #	bs-76796c-10mg
Product Name	Shogaol
Specifications
Storage Buffer	Liquid
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 555-66-8 Molecular formula: C17H24O3 Molecular weight: 276.37 Purity: >98% (HPLC) Appearance: Colourless to yellow liquid. Solubility: Soluble in DMSO (10mg/ml). InChiKey: OQWKEEOHDMUXEO-BQYQJAHWSA-N SMILES: OC1=CC=C(CCC(/C=C/CCCCC)=O)C=C1OC SMILES: CCCCCC=CC(=O)CCC1=CC(OC)=C(O)C=C1
Description	Shogaol is a pungent bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory, anticancer, antioxidant, neuroprotective, antidiabetic, cardioprotective and antimicrobial properties. The anticancer activity is associated with the induction of apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairment of tubulin polymerization, downregulation of STAT3 and NF-kappaB signaling, inhibition of the expression of inflammatory mediators and suppresseion of Toll-like receptor signaling. It also has been shown to induce autophagy and activate peroxisomal proliferator activated receptor gamma (PPARgamma). 6-Shogaol can also activate both TRPV1 and TRPA1 channels. 6-Shogaol inhibits the NF-kappaB and NLRP3 signaling pathways.