Tangeretin

Overview
Catalog #	bs-76856c-5mg
Product Name	Tangeretin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 481-53-8 Molecular formula: C20H20O7 Molecular weight: 372.37 Purity: >98% (HPLC) Appearance: White to pale yellow powder. Solubility: Soluble in DMSO (10mg/ml) or DMF (10mg/ml). Sparingly soluble in ethanol (0,5 mg/ml). InChiKey: ULSUXBXHSYSGDT-UHFFFAOYSA-N SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C31 SMILES: COC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C(OC)=C(OC)C(OC)=C2OC
Description	Tangeritin is a polymethoxylated flavone isolated from peels of citrus fruits with antiproliferative and antioxidant properties. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells and blocking p38 MAPK, JNK, and Akt activation in interleukin-1beta-stimulated human lung carcinoma A549 cells. It is described to block cell cycle progression at G1 and induce apoptosis. Shows anti-inflammatory, osteoprotective and neuroprotective effects. Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells. Shown to be a Notch-1 inhibitor. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways and has been shown to antagonize ABCB1-mediated multidrug resistance.