Telmisartan

Overview
Catalog #	bs-76863c-10mg
Product Name	Telmisartan
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 144701-48-4 Molecular formula: C33H30N4O2 Molecular weight: 514.62 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO, chloroform, DMF or ethanol. InChiKey: RMMXLENWKUUMAY-UHFFFAOYSA-N SMILES: CN1C2=CC=CC=C2N=C1C3=CC(N(CC4=CC=C(C5=CC=CC=C5C(O)=O)C=C4)C(CCC)=N6)=C6C(C)=C3 SMILES: CCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=O
Description	Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively inhibits the angiotensin II AT1 receptor subtype (Ki=3.7nM). Telmisartan exhibits antihypertensive activity in a renin-dependent model of hypertension. In addition to blocking the renin-angiotensin system (RAS), telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-gamma), a central regulator of insulin and glucose metabolism and improving insulin sensitivity. It is believed that telmisartan's dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk and glomerulosclerosis. Furthermore, telmisartan inhibits proliferation in several cancer models by inducing apoptosis and cell cycle arrest.