BML-277

Overview
Catalog #	bs-82012c-5mg
Product Name	BML-277
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM).
Description	CAS Number: 516480-79-8 Chemical Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide Molecular weight: 363.81 Formula: C20H14ClN3O2 Solubility: DMSO (20 mg/ml); Ethanol (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC [50% ethyl acetate in hexanes; Rf = 0.17] NMR conforms