KL-001

Overview
Catalog #	bs-82228c-5mg
Product Name	KL-001
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
Description	CAS Number: 309928-48-1 Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide Molecular weight: 398.46 Formula: C21H22N2O4S Solubility: DMSO (100 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)