Selinexor

Overview
Catalog #	bs-82754c-5mg
Product Name	Selinexor
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.
Description	CAS Number: 1393477-72-9 Chemical Name: (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide; Molecular weight: 443.31 Formula: C17H11F6N7O Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)