NVP-231

Overview
Catalog #	bs-82993c-5mg
Product Name	NVP-231
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
Description	CAS Number: 362003-83-6 Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Molecular weight: 431.55 Formula: C25H25N3O3S Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)