IM-12

Overview
Catalog #	bs-83094c-5-mg
Product Name	IM-12
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt--catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4
Description	CAS Number: 1129669-05-1 Chemical Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Molecular weight: 377.41 Formula: C22H20FN3O2 Solubility: DMSO (50 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC NMR (Conforms)