Phenylhexyl isothiocyanate

Overview
Catalog #	bs-83106c-5-mg
Product Name	Phenylhexyl isothiocyanate
Specifications
Conjugation	Unconjugated
Storage Buffer	White solid
Storage Condition	-20°C
Target
Background	Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC was the most potent in a series of synthetic arylalkyl isothiocyanates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model.2 It was also found to induce apoptosis and inhibit leukemia cell growth in vivo3 and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent4. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.5