ABT-869

Overview
Catalog #	bs-83107c-5-mg
Product Name	ABT-869
Specifications
Storage Buffer	Colorless to pale yellow liquid
Storage Condition	-20°C
Target
Product Information	ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5
Description	CAS Number: 796967-16-3 Chemical Name: 1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea Molecular weight: 375.41 Formula: C21H18FN5O Solubility: DMSO (30 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)