Get 20% off all conjugated antibody purchases with code "CON-ANTIBODY2025"! Offer valid on direct orders only. Available for US customers and internationally through distributors.

SM-164

Overview
Catalog # bs-83122c-1-mg
Product Name SM-164
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6
Description CAS Number: 957135-43-2

Chemical Name: (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide

Molecular weight: 1121.45

Formula: C62H84N14O6

Solubility: DMSO (50 mg/ml)

Physical Properties: White to pale-yellow solid

Purity: 98% by HPLC NMR (Conforms)