SM-164

Overview
Catalog #	bs-83122c-1-mg
Product Name	SM-164
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6
Description	CAS Number: 957135-43-2 Chemical Name: (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide Molecular weight: 1121.45 Formula: C62H84N14O6 Solubility: DMSO (50 mg/ml) Physical Properties: White to pale-yellow solid Purity: 98% by HPLC NMR (Conforms)