GW788388
| Overview | |
| Catalog # | bs-83131c-5-mg |
| Product Name | GW788388 |
| Specifications | |
| Conjugation | Unconjugated |
| Storage Buffer | Pale pink solid |
| Storage Condition | -20°C |
| Target | |
| Background | Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase.1,2 Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models.3,4 GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.5 |
Powered by Bioz