Necrostatin-1
| Overview | |
| Catalog # | bs-83160c-50mg |
| Product Name | Necrostatin-1 |
| Specifications | |
| Storage Buffer | Pale yellow solid |
| Storage Condition | RT |
| Target | |
| Product Information | Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4. |
| Description | CAS Number: 4311-88-0 Chemical Name: Necroptosis inhibitor Molecular Weight: 259.33 Formula: C13H13N3OS Solubility: DMSO (20 mg/ml) Ethanol (5 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by TLC [5% methanol in methylene chloride, Rf = 0.37] NMR Conforms |
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