SB 203580

Overview
Catalog #	bs-83266c-25mg
Product Name	SB 203580
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM2. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function3.
Description	CAS Number: 152121-47-6 Chemical Name: p38 MAP kinase inhibitor Molecular Weight: 377.44 Formula: C21H16N3OSF Solubility: DMSO (100 mg/ml) Ethanol (10 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (conforms)