Cabozantinib
| Overview | |
| Catalog # | bs-83349c-25mg |
| Product Name | Cabozantinib |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 μM respectively.1 Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model.2 Clinically useful anticancer agent.3 |
| Description | CAS Number: 849217-68-1 Chemical Name: Met and VEGFR2 inhibitor Molecular Weight: 501.51 Formula: C28H24FN3O5 Solubility: DMSO Physical Properties: White solid Purity: 98% by HPLC, NMR (Conforms) |
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