Lipofermata

Overview
Catalog #	bs-83366c-50mg
Product Name	Lipofermata
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
Description	CAS Number: 297180-15-5 Chemical Name: Fatty acid transport protein 2 (FATP2) inhibitor Molecular Weight: 360.23 Formula: C15H10BrN3OS Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98%, NMR (Conforms)