RO-3306

Overview
Catalog #	bs-83377c-25mg
Product Name	RO-3306
Specifications
Storage Buffer	Off-white or pale yellow solid
Storage Condition	-20°C
Target
Product Information	RO-3306 is a selective inhibitor of CDK1 (IC50 = 35 nM versus CDK2 IC50 = 340nM).1,2 It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4 It has also been demonstrated to overcome apoptotic resistance in BRAFV600E human colorectal cancer cells.5
Description	CAS Number: 872573-93-8 Chemical Name: CDK1 inhibitor Molecular Weight: 351.45 Formula: C18H13N3OS2 Solubility: DMSO (15 mg/ml) Physical Properties: Off-white or pale yellow solid Purity: 98% by HPLC NMR (Conforms)