GS-441524
| Overview | |
| Catalog # | bs-83389c-50mg |
| Product Name | GS-441524 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs. |
| Description | CAS Number: 1191237-69-0 Chemical Name: Remdesivir active metabolite Molecular Weight: 291.27 Formula: C12H13N5O4 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms) |
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