AGI-5198

Overview
Catalog #	bs-83401c-25mg
Product Name	AGI-5198
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG).
Description	CAS Number: 1355326-35-0 Chemical Name: R132 mutant isocitrate dehydrogenase inhibitor Molecular Weight: 462.56 Formula: C27H31FN4O2 Solubility: DMSO (10 mg/ml) Ethanol (5 mg/ml) Physical Properties: White solid Purity: 98% by HPLC, NMR (Conforms)