MLS-544460

Overview
Catalog #	bs-83436c-25mg
Product Name	MLS-544460
Specifications
Storage Buffer	Cream/off-white solid
Storage Condition	-20°C
Target
Product Information	MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
Description	CAS Number: 352336-36-8 Chemical Name: Eya2 phosphatase inhibitor Molecular Weight: 341.36 Formula: C17H12FN3O2S Solubility: DMSO (40 mg/ml) Physical Properties: Cream/off-white solid Purity: >98% by TLC NMR (Conforms)