KNK437

Overview
Catalog #	bs-83441c-25mg
Product Name	KNK437
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Inhibits constitutive and inducible HSP70 expression in non-stressed1 and heat-stressed2 cancer cells. Blocks the geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling.3 Inhibits leukocyte integrin α4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1) suggesting that HSP70 is essential for ß7 integrin signalling.4 Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg).5
Description	CAS Number: 218924-25-5 Chemical Name: Inhibits HSP70 expression Molecular Weight: 245.23 Formula: C13H11NO4 Solubility: DMSO (30 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)