TTK21
| Overview | |
| Catalog # | bs-83454c-25mg |
| Product Name | TTK21 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | TTK21 (709676-56-2) is a novel activator of CBP/p300 acetyl transferases.1 When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels.1 It reinstated plasticity and memory in a tauopathy mouse model2, ameliorated Aβ-impaired long term potentiation3 and promoted axon growth, sprouting and synaptic plasticity in chronic experimental spinal cord injury4. |
| Description | CAS Number: 709676-56-2 Chemical Name: CBP/p300 histone acetyltransferase activator Molecular Weight: 357.76 Formula: C17H15ClF3NO2 Solubility: DMSO (50 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms) |
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