E3330

Overview
Catalog #	bs-83746c-5mg
Product Name	E3330
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	E3330 is a hepatoprotective benzoquinone that inhibits TNF-α release via decreasing NFkB activation.1,2 It also is an inhibitor of AP endonuclease 1 (APE1) redox function.3 E3330 acts synergistically with cisplatin to increase cytotoxicity and impair cell migration and invasion in non-small cell lung cancer.4 Inhibition of APE1 with E3330 induces ferroptosis via impairment of AKT phosphorylation ultimately leading to Nrf2 degradation.5 It sensitizes osteosarcoma cells to ionizing radiation via ferroptosis induction.6
Description	CAS Number: 136164-66-4 Chemical Name: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid Molecular Weight: 378.47 Formula: C21H30O6 Solubility: DMSO (>50 mg/ml) Physical Properties: Orange solid Purity: >98% by HPLC, NMR (Conforms)