Sotrastaurin

Overview
Catalog #	bs-83765c-5mg
Product Name	Sotrastaurin
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Sotrastaurin is a highly selective and potent (IC50’s for PKC isotypes: α = 2.1 nM, ß1 = 2.0 nM, δ = 1.3 nM, ε = 6.2 nM, η = 6.1 nM, Θ = 1.0 nM) pan-PKC inhibitor.1 Potent immunomodulatory agent that inhibits early T-cell activation and displays potential for the prevention of transplant rejection and the treatment of inflammatory diseases.2,3 Sotrastaurin has anticancer activity in various cancer models including breast4, CLL5, ocular melanoma6, and B-cell lymphoma7.
Description	CAS Number: 425637-18-9 Chemical Name: 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Molecular Weight: 438.49 Formula: C25H22N6O2 Solubility: DMSO (>25 mg/ml) Physical Properties: Orange solid Purity: >98% by HPLC NMR (Conforms)