FB23-2

Overview
Catalog #	bs-83809c-5mg
Product Name	FB23-2
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	FB23-2 is an inhibitor (IC50 = 2.6 µM) of the mRNA m6A demethylase fat-mass- and obesity-associated protein (FTO).1 Displays significant anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. Selective against the RNA demethylase ALKB5. FB23-2 induced myeloid differentiation and apoptosis in acute myeloid leukemia cells. FB23-2 suppressed the proliferation and migration of hepatocellular carcinoma cells via suppressing the expression of the kinase ERBB3 and human tubulin beta class Iva (TUBB4A).2
Description	CAS Number: 2243736-45-8 Chemical Name: 2-[2,6-Dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]-N-hydroxybenzamide Molecular Weight: 392.24 Formula: C18H15Cl2N3O3 Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)