NVP-2

Overview
Catalog #	bs-83811c-5mg
Product Name	NVP-2
Specifications
Storage Buffer	Off-white to beige solid
Storage Condition	-20°C
Target
Product Information	NVP-2 is a highly selective and potent (IC50 = 0.514 nM) inhibitor of cyclin dependent kinase 9 (CDK9).1 It inhibited proliferation of MOLT4 cells (IC50 = 9 nM). Treatment of cells with NVP-2 resulted in profound downregulation of core regulatory circuitry genes. It has also been shown to be a potent inhibitor of CDK10 (IC50 = 29 nM; this study gives an IC50 of 6 nM for CDK9).2 NVP-2 acted synergistically with orlistat to inhibit acute myeloid leukemia cells (IC50s: Kasumi-1 cells 7.58 nM; U937 cells 8.99 nM).3
Description	CAS Number: 1263373-43-8 Chemical Name: 4-[[[6-[5-Chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrile Molecular Weight: 513.08 Formula: C27H37ClN6O2 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white to beige solid Purity: >98% by HPLC NMR (Conforms)