MZ1

Overview
Catalog #	bs-83830c-1mg
Product Name	MZ1
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3.1 It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B.2 An important tool for studying the effects of BRD4 degradation in cancer therapy.3
Description	CAS Number: 1797406-69-9 Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Molecular Weight: 1002.64 Formula: C49H60ClN9O8S2 Solubility: DMSO (100 mg/ml) Physical Properties: Pale-yellow solid Purity: >98% by HPLC NMR (Conforms)