| Overview |
| bsm-52434r-pbs-only-100ul |
| Lactate Dehydrogenase (2D9) Monoclonal Antibody, PBS Only Conjugated |
| WB, IHC-P, IHC-F, IP, IF, Flow-Cyt, ICC/IF |
| Human |
| Specifications |
| PBS Only |
| Rabbit |
| Human Lactate Dehydrogenase between 250 to C-terminus |
| Monoclonal |
| 2D9 |
| IgG |
| Lot Dependent |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 3939 |
| P00338 |
| L-lactate dehydrogenase A chain, Cell prolifeRation-inducing gene 19 protein, LDH muscle subunit, Renal carcinoma antigen NY-REN-59, L-lactate dehydrogenase B chain, LDH heart subunit, Renal carcinoma antigen NY-REN-46, LDH-A, LDH-M, LDHA, PIG19, LDH-B, LDH-H, LDHB |
| Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 8489% sequence similarities and 6975% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure.
The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. |
| Application Dilution |
| WB |
1:500-2000 |
| IHC-P |
1:100-200 |
| IHC-F |
1:100-200 |
| IP |
1:20-50 |
| IF |
1:100-200 |
| Flow-Cyt |
1:50-100 |
| ICC/IF |
1:50-200 |
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