| Overview |
| bsm-54335r-pbs-only-100ul |
| CD46 Recombinant Antibody, PBS Only Conjugated |
| WB, IHC-P, IHC-F, IF(IHC-P), IF(ICC) |
| Human |
| Specifications |
| PBS Only |
| Rabbit |
| Synthetic peptide within human CD46 aa 50-100 |
| Monoclonal |
| 4C3 |
| IgG |
| Lot Dependent |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 4179 |
| P15529 |
| Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; MCP; MIC10; AHUS2; |
| Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
| Application Dilution |
| WB |
1:500-2000 |
| IHC-P |
IHC-P1:100-500 |
| IHC-F |
IHC-F1:100-500 |
| IF(IHC-P) |
IFIHC-P1:100-500 |
| IF(ICC) |
IFICC1:50-200 |
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