Alpha-synuclein (nitro-Tyr39) Polyclonal Antibody

Applications

IHC-P
IHC-F
IF
Flow-Cyt

Reactivity

Human
Mouse
Rat

Overview
Catalog #	bs-9587R
Product Name	Alpha-synuclein (nitro-Tyr39) Polyclonal Antibody
Applications	IHC-P, IHC-F, IF, Flow-Cyt
Reactivity	Human, Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic nitrylpeptide derived from human Alpha-synuclein around nitration site of Tyr39
Modification Site	Tyr39
Clonality	Polyclonal
Clone #	#REF!
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4_. Store at -20_ for one year. Avoid repeated freeze/thaw cycles.
Target
Synonyms	SYUA_HUMAN; nitrated Alpha-synuclein nitrated-Tyr39; nitrated Alpha-synuclein nitro-Tyr39; Alpha-synuclein nitro-Tyr39; Alpha-synuclein nitro Tyr39; nitrated Alpha synuclein; nitrated Alpha-Synuclein; Alpha synuclein; Alpha-synuclein, isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease familial 1; PD 1; PD1; SNCA; Snca synuclein, alpha non A4 component of amyloid precursor; Synuclein alpha; Synuclein, alpha non A4 component of amyloid precursor.
Background	The synuclein family members, including Alpha-synuclein (also designated NACP for non-Beta-Amyloid component) and Beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. Alpha-synuclein is localized to neuronal cell bodies and synapses. Alpha-synuclein was first identified as a component of Alzheimer?s disease amyloid plaques. Abnormal platelet function in Alzheimer?s disease has been demonstrated. During megakaryocytic differentiation Alpha-synuclein has been found to be upregulated, while Beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of Alpha-synuclein has been found in patients with early onset Parkinson?s disease.
Application Dilution
IHC-P	WB1:300-5000
IHC-F	IHC-P1:200-400
IF	IHC-P1:50-200
Flow-Cyt