| Overview |
| bs-0324R-PE |
| C5a anaphylatoxin Polyclonal Antibody, PE Conjugated |
| WB |
| Human, Mouse |
| Rat |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from mouse C5a (725-770aa) |
| 701-755/1680 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 15139 |
| P06684 |
| Secreted |
| C5; He; C5a; Complement C5; Hemolytic complement; Hc |
| Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
| Application Dilution |
| WB |
1:300-5000 |
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