CCL5/RANTES Polyclonal Antibody, HRP Conjugated

Applications

ELISA
IHC-P
IHC-F

Reactivity

Human
Mouse
Pig
Guinea Pig

Predicted Reactivity

Rat
Dog
Cow
Sheep
Rabbit

Overview
Catalog #	bs-1324R-HRP
Product Name	CCL5/RANTES Polyclonal Antibody, HRP Conjugated
Applications	ELISA, IHC-P, IHC-F
Reactivity	Human, Mouse, Pig, Guinea Pig
Predicted Reactivity	Rat, Dog, Cow, Sheep, Rabbit
Specifications
Conjugation	HRP
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human CCL5
Immunogen Range	62-91/91
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	6352
Swiss Prot	P13501
Subcellular location	Secreted
Synonyms	SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; Eosinophil chemotactic cytokine; Small-inducible cytokine A5; T cell-specific protein P228; T-cell-specific protein RANTES; CCL5
Background	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
Application Dilution
ELISA	1:500-1000
IHC-P	1:200-400
IHC-F	1:100-500

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