Cathepsin K Polyclonal Antibody

Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-Cathepsin K Polyclonal Antibody, Unconjugated (bs-1611R) at 1:200 followed by conjugation to the secondary antibody, (SP-0023), and DAB staining

$Lane 1: Mouse Raw264.7 cell lysates; Lane 2: Mouse 4T1 cell lysates probed with Cathepsin K Polyclonal Antibody, Unconjugated (bs-1611R) at 1:1000 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.$

Lane 1: Mouse Raw264.7 cell lysates; Lane 2: Mouse 4T1 cell lysates probed with Cathepsin K Polyclonal Antibody, Unconjugated (bs-1611R) at 1:1000 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.

Applications

WB
IHC-P
IHC-F
IF

Reactivity

Mouse
Rat

Overview
Catalog #	bs-1611R
Product Name	Cathepsin K Polyclonal Antibody
Applications	WB IHC-P IHC-F IF
Reactivity	Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human Capsin K
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20C for 12 months.
Target
Gene ID	1513
Synonyms	Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK.
Background	The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008].
Application Dilution
WB	1:500-2000
IHC-P
IHC-F
IF