IKK alpha / beta (S180/S181) Antibody, HRP Conjugated

Applications

ELISA
IHC-P
IHC-F

Reactivity

Mouse

Predicted Reactivity

Human
Rat
Cow
Sheep
Pig
Horse

Overview
Catalog #	bs-3236R-HRP
Product Name	IKK alpha / beta (S180/S181) Antibody, HRP Conjugated
Applications	ELISA, IHC-P, IHC-F
Reactivity	Mouse
Predicted Reactivity	Human, Rat, Cow, Sheep, Pig, Horse
Specifications
Conjugation	HRP
Host	Rabbit
Source	KLH conjugated synthetic phosphopeptide derived from human IKK alpha/IKK beta around the phosphorylation site of Ser180/Ser181
Modification Site	Ser180/Ser181
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	1147
Subcellular location	Cytoplasm, Nucleus
Synonyms	I Kappa B Kinase Alpha; IKKalpha; IKK alpha; IkappaB kinase; IkB kinase alpha subunit; IKBKA; IKK 1; IKK A; IKK a kinase; IKK1; IKKA; Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells; Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit; NFKBIKA; Nuclear Factor Kappa B Inhibitor Kinase Alpha; Nuclear factor NF kappa B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor; TCF16; CHUK1; Conserved Helix Loop Helix Ubiquitous Kinase; Conserved helix loop ubiquitous kinase; I Kappa B Kinase 1; IKKA_HUMAN.
Background	Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.
Application Dilution
ELISA	1:500-1000
IHC-P	1:200-400
IHC-F	1:100-500

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