14-3-3 beta Polyclonal Antibody

Applications

  • WB

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-50553R
Product Name 14-3-3 beta Polyclonal Antibody
Applications WB
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant human protein purified from E.coli
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein G.
Storage HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Store for 1 year at -20°C from date of shipment.
Target
Gene ID 7529
Swiss Prot P31946
Synonyms HS1; GW128; YWHAA; KCIP-1; HEL-S-1; 14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; YWHAB
Background Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activatation of MAP kinases via AKAP13.
Application Dilution
WB 1:300-1000