| Overview |
| bs-51052R |
| TIP5 Polyclonal Antibody |
| WB |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Polyclonal antibody raised in rabbit against TIP5 (Transcription termination factor I-interacting protein 5), using the recombinant protein |
| Polyclonal |
| Not determined |
| Not Determined |
| Whole antiserum from rabbit containing 0.05% azide |
| Serum with 0.05% sodium azide. |
| Store at -20°C for 12 months. |
| Target |
| 11176 |
| Q9UIF9 |
| Bromodomain adjacent to zinc finger domain protein 2A, BAZ2A, Transcription termination factor I-interacting protein 5, TTF-I-interacting protein 5, Tip5, hWALp3 |
| Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing. |
| Application Dilution |
| WB |
1:300-5000 |
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