| Overview |
| bs-5999R-PE |
| DAB2 Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Human, Rat |
| Mouse, Dog, Cow, Pig, Horse, Chicken, Rabbit, Guinea Pig |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human DAB2 |
| 31-130/770 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 1601 |
| P98082 |
| Cytoplasm |
| DOC2; DOC-2; Disabled homolog 2; Differentially-expressed protein 2; DAB2 |
| This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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