Clavesin Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-70043r |
| Product Name | Clavesin Antibody |
| Applications |
WB
|
| Specificity | Specific for endogenous levels of the ~35 kDa clavesin 1/2 protein doublet. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively. |
| Reactivity | Rat |
| Predicted Reactivity | Human, Mouse |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat Clavesin 1, conjugated to keyhole limpet hemocyanin (KLH). |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | Affinity purification |
| Storage Buffer | PBS + 50% glycerol |
| Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target | |
| Gene ID | 366311 |
| Swiss Prot | A6JFQ6 |
| Synonyms | 4 antibody, C6orf212 antibody, C6orf213 antibody, Clavesin 1 antibody, Clavesin 2 antibody, CRALBPL antibody, FLJ37248 antibody, MGC120572 antibody, MGC34646 antibody, OTTHUMP00000017122 antibody, Retinaldehyde binding protein 1 like 1 antibody, Retinaldehyde binding protein 1 like 2 antibody, RLBP1L1 antibody, RLBP1L2 antibody |
| Background | Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008). |
| Application Dilution | |
| WB | 1:300-5000 |