| Overview |
| bs-70099R |
| GABAA Receptor α4, Antibody |
| WB, IHC |
| Specific for endogenous levels of the ~ 64 kDa α4-subunit of the GABAA receptor. |
| Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Fusion protein from the cytoplasmic loop of the α4 subunit of rat GABAA receptor. |
| Polyclonal |
| IgG |
| Lot Dependent |
| Antigen Affinity purification from Pooled whole antiserum |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 140675 |
| P28471 |
| GABA(A) receptor subunit alphα4 antibody, GABA(A) receptor subunit alpha-4 antibody, GABR A4 antibody, GABRα4 antibodyGabra4 antibody, Gamma aminobutyric acid (GABA) A receptor alphα4 antibody, Gamma aminobutyric acid A receptor alphα4 antibody, Gamma aminobutyric acid receptor alphα4 subunit antibody, Gamma aminobutyric acid receptor subunit alphα4 antibody, Gamma-aminobutyric acid receptor subunit alpha-4 antibody, GBRA4_HUMAN antibody |
| Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunitsresults in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
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