GABAB Receptor (Ser783), R2-Subunit Antibody
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-70111R |
Product Name | GABAB Receptor (Ser783), R2-Subunit Antibody |
Applications | WB, IHC, ICC |
Specificity | Specific for endogenous levels of the ~102 kDa GABAB R2 phosphorylated at Ser783. Immunolabeling is completely eliminated by treatment with λ-phosphatase. |
Reactivity | Mouse, Rat |
Predicted Reactivity | Human, Dog, Bovine, Chicken, Xenopus, Non-Human Primate |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 of the R2 subunit of rat GABAB recerptor, conjugated to keyhole limpet hemocyanin (KLH). |
Modification Site | Ser783 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | Lot Dependent |
Purification | Antigen Affinity purification from Pooled whole antiserum |
Storage Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
Target | |
Gene ID | 83633 |
Swiss Prot | O88871 |
Synonyms | BcDNA:GH07312 antibody, CG6706 antibody, CT20836 antibody, D Gaba2 antibody, FLJ36928 antibody, G protein coupled receptor 51 antibody, G-protein coupled receptor 51 antibody, GAB B R2 antibody, GABA B R2 antibody, GABA B receptor 2 antibody, GABA-B receptor 2 antibody, GABA-B-R2 antibody, GABA-BR2 antibody, GABAB R2 antibody, GABABR 2 antibody, GABABR2 antibody, GABB R2 antibody, GABBR 2 antibody, Gabbr2 antibody, GABR2_HUMAN antibody, Gamma aminobutyric acid B receptor 2 antibody, Gamma aminobutyric acid GABA B receptor 2 antibody, Gamma aminobutyric acid type B receptor subunit 2 antibody, Gamma-aminobutyric acid type B receptor subunit 2 antibody, Gb 2 antibody, Gb2 antibody, GH07312 antibody, GPR 51 antibody, GPR51 antibody, GPRC 3B antibody, GPRC3B antibody, HG 20 antibody, HG20 antibody, HRIHFB2099 antibody, Metabotropic GABA B receptor subtype 2 antibody, OTTHUMP00000021776 antibody, OTTHUMP00000063797 antibody, R2 SUBUNIT antibody |
Background | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABA-B receptors and phosphorylates Ser-783 in the cytoplasmic tail of the R2 subunit and that Ser-783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of Ser-783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007). |
Application Dilution | |
WB | 1:300-5000 |
IHC | |
ICC | 1:100-500 |