MeCP2 Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-70148CH |
| Product Name | MeCP2 Antibody |
| Applications | WB, IHC |
| Specificity | Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates. |
| Reactivity | Human, Mouse, Rat, Non-Human Primate |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Chicken |
| Source | Full length human recombinant MeCP2 |
| Clonality | Polyclonal |
| Isotype | IgY |
| Concentration | Lot Dependent |
| Purification | Total IgY fraction |
| Storage Buffer | PBS + 5 mM NaN3. |
| Storage Condition | Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target | |
| Gene ID | 4204 |
| Swiss Prot | P51608 |
| Synonyms | AUTSX 3 antibody, AUTSX3 antibody, DKFZp686A24160 antibody, Mbd 5 antibody, Mbd5 antibody, MECP 2 antibody, MeCP 2 protein antibody, MeCP-2 protein antibody, Mecp2 antibody, MECP2_HUMAN antibody, Methyl CpG binding protein 2 (Rett syndrome) antibody, Methyl CpG binding protein 2 antibody, Methyl-CpG-binding protein 2 antibody, MRX 16 antibody, MRX 79 antibody, MRX16 antibody, MRX79 antibody, MRXS 13 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, WBP 10 antibody, WBP10 antibody |
| Background | MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | |
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