| Overview |
| bs-70157R |
| Metabotropic Glutamate Receptor 1a Antibody |
| WB, IHC |
| Specific for endogenous levels of the ~125 kDa monomer and the ~250 kDa mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody. |
| Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat mGluR1a, conjugated to keyhole limpet hemocyanin (KLH). |
| Polyclonal |
| IgG |
| Lot Dependent |
| Antigen Affinity purification |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 24414 |
| P23385 |
| Glutamate receptor metabotropic 1 antibody, GPRC1A antibody, GRM1 alpha antibody, GRM1 antibody, GRM1_HUMAN antibody, Metabotropic glutamate receptor 1 antibody, MGLU1 antibody, mGluR1 antibody, SCAR13 antibody |
| The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
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