| Overview |
| bs-70177r-100ul |
| Nicotinic Acetylcholine Receptor (nAChR) β2 Antibody |
| WB |
| Specific for endogenous levels of the ~52 kDa nAChRβ2 protein. |
| Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Fusion protein from the cytoplasmic loop of the β2 subunit of mouse nAChR. |
| Polyclonal |
| IgG |
| Lot Dependent |
| Antigen Affinity purification from Pooled whole antiserum |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 11444 |
| Q9ERK7 |
| Acetylcholine receptor beta 2 neural antibody, ACHB2_HUMAN antibody, ACHN antibody, AChR antibody, Acrb 2 antibody, Acrb2 antibody, b2 nAchR antibody, Cholinergic receptor nicotinic beta 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 neuronal antibody, cholinergic receptor nicotinic beta 2 (neuronal) antibody, Chrnb2 antibody, EFNL 3 antibody, EFNL3 antibody, nAChRB2 antibody, Neuronal acetylcholine receptor protein beta 2 chain precursor antibody, Neuronal acetylcholine receptor protein subunit beta 2 antibody, Neuronal acetylcholine receptor subunit beta-2 antibody, Neuronal nicotinic acetylcholine receptor beta 2 antibody |
| Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits α4β2, whereas α3β4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, β2-containing receptors greatly outnumber receptors that contain β4 (McGehee & Role, 1995; Albuquerque, et al., 2009), and in most brain regions, targeted deletion of the β2 subunit virtually abolishes [3H]-epibatidine binding and receptor autoradiography (Zoli, et al., 1998) due to the absence of a β subunit required to form functional nAChRs (Champtiaux & Changeux, 2004). |
| Application Dilution |
| WB |
1:300-5000 |
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