| Overview |
| bs-70220R |
| Periostin pan Antibody |
| WB, IHC |
| Specific for endogenous levels of the three periostin bands around ~93 kDa. The immunogenic peptide is present in all known splice variants of periostin and therefore this antibody recognizes all known molecular forms of periostin. The antibody also works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH6.0)/ 0.1 % Tween-20). |
| Human, Mouse, Rat, Chicken |
| Dog, Bovine, Sheep, Horse, Cat, Rabbit, Guinea Pig, Goat, Zebrafish, Fish, Hamster, Xenopus, Non-Human Primate, Vole, Finch |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide corresponding to amino acid residues from the fasciclin domain 1 of mouse periostin. |
| Polyclonal |
| IgG |
| Lot Dependent |
| Antigen Affinity purification |
| PBS |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| 50706 |
| Q62009 |
| Fasciclin-I like antibody, MGC119510 antibody, MGC119511 antibody, OSF 2 antibody, OSF-2 antibody, OSF2 antibody, Osteoblast specific factor 2 (fasciclin I like) antibody, Osteoblast specific factor 2 antibody, Osteoblast specific factor antibody, Osteoblast-specific factor 2 antibody, PDLPOSTN antibody, Periodontal ligament specific periostin antibody, Periostin antibody, Periostin isoform thy2 antibody, Periostin isoform thy4 antibody, Periostin isoform thy6 antibody, Periostin isoform thy8 antibody, Periostin osteoblast specific factor antibody, PN antibody, POSTN antibody, POSTN_HUMAN antibody, RP11 412K4.1 antibody |
| Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008) |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
Powered by Bioz