| Overview |
| bsm-41365r-pbs-only-100ul |
| Beclin 1 Recombinant Antibody, PBS Only Conjugated |
| WB, IHC-P, IHC-F, IF(IHC-P) |
| Human, Rat |
| Mouse |
| Specifications |
| PBS Only |
| Rabbit |
| Recombinant human Beclin 1 protein |
| 141-450/450 |
| Recombinant |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 8678 |
| Q14457 |
| Cytoplasm, Cell membrane |
| Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN. |
| Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. |
| Application Dilution |
| WB |
1:200-1000 |
| IHC-P |
IHC-P1:50-200 |
| IHC-F |
IHC-F1:50-200 |
| IF(IHC-P) |
IFIHC-P1:50-200 |
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