Overview |
bsm-51055M |
PRKAA2 (6C2) Monoclonal Antibody |
WB, IF |
Human |
Specifications |
Unconjugated |
Mouse |
This PRKAA2 monoclonal antibody is generated from mouse immunized with PRKAA2 recombinant protein. |
Monoclonal |
6C2 |
IgG2a |
0.5ug/ul |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
5563 |
P54646 |
AMPK; AMPK2; PRKAA; AMPKa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; PRKAA2 |
The protein encoded by this gene is a catalytic subunit of
the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer
consisting of an alpha catalytic subunit, and non-catalytic beta
and gamma subunits. AMPK is an important energy-sensing enzyme that
monitors cellular energy status. In response to cellular metabolic
stresses, AMPK is activated, and thus phosphorylates and
inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy
beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in
regulating de novo biosynthesis of fatty acid and cholesterol.
Studies of the mouse counterpart suggest that this catalytic
subunit may control whole-body insulin sensitivity and is necessary
for maintaining myocardial energy homeostasis during ischemia. |
Application Dilution |
WB |
1:300-5000 |
IF |
|