| Overview |
| bsm-51116M |
| LGR5/GPR49 (9C1) Monoclonal Antibody |
| WB, FCM |
| Human |
| Specifications |
| Unconjugated |
| Mouse |
| This LGR5/GPR49 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 689-719 amino acids from human LGR5/GPR49. |
| Monoclonal |
| 9C1 |
| IgG1 |
| 0.5ug/ul |
| Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 8549 |
| O75473 |
| FEX; HG38; GPR49; GPR67; GRP49; Leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; LGR5 |
| Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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