| Overview |
| bsm-52204R |
| Smad2(S255) (8C12) Monoclonal Antibody |
| WB, IHC-P |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide derived from human Smad2(S255), around 220-280aa (phospho S255). |
| S255 |
| Monoclonal |
| 8C12 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at -20°C for 12 months. |
| Target |
| 4087 |
| Q15796 |
| JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2 |
| Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Application Dilution |
| WB |
1:500-1000 |
| IHC-P |
1:50-200 |
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