| Overview |
| bsm-52223r-bf405-100ul |
| Smad2 Recombinant Antibody, AbBy Fluor-405 Conjugated |
| WB, IF, Flow-Cyt |
| Human, Mouse, Rat |
| Specifications |
| AbBy Fluor-405 |
| Rabbit |
| Recombinant human Smad2 protein, around N-terminal 1-200aa. |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 4087 |
| Q15796 |
| JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2 |
| Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Application Dilution |
| WB |
1:300-5000 |
| IF |
|
| Flow-Cyt |
1ug/Test |
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