MAP2K1/2 Recombinant Antibody, Cy5 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bsm-52280r-cy5 |
| Product Name | MAP2K1/2 Recombinant Antibody, Cy5 Conjugated |
| Applications |
WB
IF
|
| Specificity | The antibody will detect both MAP2K1 and MAP2K2 |
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Cy5 |
| Host | Rabbit |
| Source | Human MAP2K1 + MAP2K2 aa 1 to the C-terminus |
| Clonality | Monoclonal |
| Clone # | 4H7 |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 5604; 5605 |
| Swiss Prot | Q02750; P36507 |
| Subcellular location | Cytoplasm, Nucleus, Mitochondrion |
| Synonyms | Dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1; MAP2K1; MEK1; MKK2; PRKMK1; MAPKK1; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAPK/ERK kinase 2; MAP2K2; MEK2; MKK2; PRKMK2; MAPKK2 |
| Background | A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway. |
| Application Dilution | |
| WB | 1:300-5000 |
| IF | |